The Notch connection

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چکیده

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Notch

The crux of development is that different cells need to be instructed to follow different developmental decisions. This involves signalling between cells so that each cell knows what its neighbour is doing. The Notch protein is pivotal for communication between cells during development and if Notch activity is perturbed, a cell may no longer be aware of which fate it should adopt. One consequen...

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The Notch proteins

What are their known functions? They are best known for their role in ‘lateral inhibition’ in the developing fruitfly nervous system and in ‘lateral specification’ of several tissues in C. elegans. To put it simply, cells in a developing tissue communicate with one another through Notch receptors and their ligands. Those that receive a Notch signal assume one fate, whereas those that do not rec...

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ژورنال

عنوان ژورنال: Nature

سال: 1995

ISSN: 0028-0836,1476-4687

DOI: 10.1038/375736a0